Inherited and sporadic medullary thyroid cancer (MTC) is an uncommon and challenging malignancy. Its low incidence has limited both widespread clinical expertise and definitive randomized clinical trials. Scientific advances relevant to MTC are reported in a wide range of literature including subspecialty publications of endocrinology, genetics, pediatrics, radiology, nuclear medicine, surgery, and oncology, which make it challenging for clinicians to remain current on all of these developments. Guidelines for the diagnosis and management of MTC have been previously published by several organizations, including some that are periodically updated in print and/or online (1–4). The American Thyroid association (ATA) chose to create specific MTC Clinical Guidelines that would bring together and update the diverse MTC literature and combine it with evidence-based medicine and input from a panel of expert clinicians.
It is our goal that these guidelines assist in the clinical care of patients; it is also our goal to share what we believe is current, rational, and optimal medical practice. In some circumstances, it may be apparent that the level of care recommended may be best provided in limited centers with specific expertise. Finally, it is not the intent of these guidelines to replace individual decision making, the wishes of the patient or family, or clinical judgment.